Despite startlingly similar backgrounds, no. Ron and Rhea Perlman aren't related.
They're about the right age for it, though: Rhea (best known, probably forever, as Carla from "Cheers") is almost exactly two years older than "Sons of Anarchy" and "Hellboy" (2004) star Ron.
They also both hail from New York City, though to be fair, it's a pretty big city. Ron's from the Washington Heights neighborhood in upper Manhattan, while Rhea was born in Coney Island in the south end of Brooklyn. They both also have Polish roots.
But one way you can tell they're not related is via a third Perlman — Phil Perlman.
In an odd reversal of the usual story, Phil followed his daughter, Rhea, into the acting business. Ever since, he's been in a number of her films and shows over the years (most notably "Cheers"), as well as those of her husband — his son-in-law — Danny DeVito ("It's Always Sunny in Philadelphia"), but he's never worked with Ron.
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