Following the events of the first film, the Abbott family, including mother Evelyn (Blunt), deaf daughter Regan (Simmonds), teenage son Marcus (Jupe) and Evelyn's newborn son, are forced to abandon their destroyed home and search for other survivors as dangerous alien creatures continue to attack remaining survivors. After Regan discovers that the high-frequency audio feedback produced from her cochlear implant hearing aid can incapacitate the creatures and make them vulnerable to killing, she makes it her mission to broadcast the frequency far and wide, allowing everyone in the vicinity to capitalize on the sound. "A Quiet Place Part II" is a sequel to the 2018 film "A Quiet Place."
After the death of his only son in a car accident, psychiatrist Philip (Affleck) turns his attention to helping his patients. When patient Daphne (Lind) takes her own life following his slightly unorthodox treatment of her, Philip and his family — his wife, Grace (Monaghan), and daughter, Lucy (Eisley) — are introduced to Daphne's brother, James (Claflin), when he returns a book to Philip that Daphne had borrowed. Inching his way into the lives of Philip and his loved ones, James' intentions begin to appear suspicious.
In Texas investigating a sex-trafficking ring case, FBI agents Karl Helter (Willis) and Rebecca Lombardi's (Fox) investigation becomes unintentionally intertwined with Texas Ranger Byron Crawford's (Hirsch) years-long search for one of the state's most dangerous serial killers. When the two agencies team up and Lombardi, while undercover, is abducted, Crawford must race to finally solve the case that has been plaguing him for years and save Lombardi's life.