Ruth Negga, Joseph Gilgun and Dominic Cooper star in "Preacher"

Jesse Custer is not a prototypical man of God. He drinks. He smokes. Of course he swears. He breaks limbs in bar brawls and he'll shoot important bits of anatomy off of anyone who'd dare try to take his dead dad's church by force. He pals around with a drug-gorging vampire and he's in love with his childhood friend, a hardened criminal. But, craziest of all, Jesse dares to confront God mano a prime mover, and insists he be given answers to all those mysteries of creation that it's generally assumed we puny humans aren't meant to know.

You might imagine that an almighty God who didn't want to be bothered by an audacious mortal could just hit the "smite" button and have done, but Jesse is special. For unknown reasons, he's been chosen as the host for a celestial being of unprecedented might that rivals God's own -- and there you have the wicked conceit of "Preacher," set to conclude its third season on AMC. Watch on Sunday, Aug. 26, as Preacher Jesse (Dominic Cooper, "Mama Mia!" 2008), on-again, off-again assassin/lover Tulip (Ruth Negga, "Agents of S.H.I.E.L.D.") and Irish bloodsucker Cassidy (Joseph Gilgun, "Misfits") try to find God and hold Him to account without any of them dying (or worse).

"Preacher" arrived at AMC after spending nearly two decades in development hell. The story was originally told in comic book format by writer Garth Ennis and artist Steve Dillon. Their 66-issue run spanned from 1995 to 2000 and was part of an era of explicit comics targeted at mature readers. Ennis, realizing the story's screen potential, started shopping it as a script in 1998, before he'd even concluded the narrative in its original medium.

Obstacles abounded, and the screen adaptation passed through multiple hands until it finally made it into the clutches of an unlikely pair, who just happened to have obsessively coveted it for years. Seth Rogen and Evan Goldberg, collaborators on "This Is the End" (2013) and other projects, grew up together and bonded over a love of Ennis' comic. The duo had been diligently dropping their names into the hat every time another round of interest in a "Preacher" adaptation sparked up, and at last, in 2013, the stars aligned: the two were commissioned to write a pilot for their dream project, eventually enlisting Sam Catlin ("Breaking Bad") as showrunner after AMC took the bait.

Casting announcements followed, with hawk-eyed fans of the source material scrutinizing every decision. Three seasons in, it's become evident that the producers nailed it, and Negga, Gilgun and Cooper have capably represented the fringe comic's beloved trio.

Cooper carries the show -- it is called "Preacher," after all, and not "Vampire" or "Trigger-Happy Bandit" -- but Negga and Gilgun give him consistent support. Season 1 began with Jesse dragging his heels as the uninspired (and uninspiring) preacher of his tiny Texas hometown of Anneville. On the verge of renouncing his duties after a crisis of faith, Jesse was forcibly inhabited by "Genesis," the offspring of a forbidden tryst between an angel and a devil. Genesis gave Jesse a pseudo-superpower known as the "Word of God" that allowed him to compel people to do anything he commanded. Jesse's ex, the viciously capable criminal Tulip O'Hare, returned to Anneville, and a centenarian Irish vampire named Cassidy fell out of the sky and began squatting at Jesse's church.

Ruth Negga in "Preacher"

Forces arrayed to contest Jesse's newfound power, including a pair of awkward angels who eventually hired a condemned Old West gunman-turned-Angel of Death to shoot Genesis out of Jesse, if necessary. The first season ended with Jesse calling up heaven via angel-phone and demanding to speak to God, then discovering that God had abandoned heaven for reasons unknown and was currently hanging out somewhere on Earth.

In season 2, Jesse, Cassidy and Tulip struck out on the great American roadtrip to find God. Their pursuit took them to New Orleans, where they were tangled with groups that included basic violent criminals, vampire covens, a Christian paramilitary called The Grail, and the voodoo-wielding Louisiana branch of Jesse's family.

Jesse's creepy extended family continues to play the villain in season 3. After Tulip's demise, Jesse was forced to look for a means of resurrection. As it turns out, voodoo is a very useful skill for bringing back the dead. The only trouble is that you might end up owing your evil Gran'ma L'Angelle (Betty Buckley, "Oz") an unspecified favor in exchange.

Meanwhile, The Grail's fixer, Herr Starr (Pip Torrens, "Star Wars: The Force Awakens," 2015), is demanding Jesse take over Messiah duties for The Grail, replacing their current inbred figurehead, and the aforementioned Angel of Death, called the Saint of Killers (Graham McTavish, "Outlander"), is still out there with the power to kill absolutely anyone, human or otherwise. Oh, and Jesse has also given up a small slice of his own soul, and the Word of God no longer reliably works for him.

All of these conflicts (and plenty more) are set to combust in the third season finale of "Preacher," and it would be a sin for any fan of smart, subversive, horror-inspired supernatural adventure to miss out. Catch the culmination of season 3 when it airs Sunday, Aug. 26, on AMC.