You can never say never to these things, but the 2017 series finale of "Grimm" gave a pretty definitive end to the show. The writers were fortunate to know well ahead of time that the show's sixth season would be its last, and so they wrote a proper ending for the show's complicated overarching storyline and its many characters.
The end was maybe a bit too definitive for some characters -- without giving away too much, quite a few major characters died at the end of the series.
"We really wanted to close the book on it," creator/writer Jim Kouf told Deadline.com.
That said, the world they created was pretty rich and wide -- the sort of mythology-building that lends itself to spinoffs. And while nothing like that is being planned, Kouf wouldn't rule it out in the future: "We leave all our options open. You just never know."
Much depends on how long the show's popularity lasts. It was a hit for NBC while it aired, but it's the shows that continue to do well after the first-run period -- the ones that succeed in reruns, DVD sales, on the fan-convention circuit and so on -- that are revived in some form after cancellation.
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